Program Manager

Program Manager – Clinical Operations (Phase 3 Cardiovascular)

We are currently partnered with an innovative clinical-stage biotechnology company developing targeted therapies for serious diseases. They are seeking an experienced Program Manager (Clinical Operations) to support and lead a late-stage global clinical development program in cardiovascular indication.

📍 Location: Preference for US East Coast, though candidates across the US or Europe will also be considered.

The Role

The Program Manager will hold end-to-end operational responsibility for a global Phase 3 clinical development program in a cardiovascular indication.

This role requires strong late-stage clinical operations expertise, a hands-on execution mindset, and the ability to manage complex global studies in a fast-paced biotech environment.

Key Responsibilities

• Lead the operational delivery of a global Phase 3 clinical program
• Oversee study planning, execution, and delivery, ensuring timelines, quality, and budget adherence
• Manage and oversee clinical sites, CROs, vendors, and central service providers
• Oversee contracts, budgets, forecasts, timelines, and study deliverables
• Coordinate global clinical trial activities across multiple regions
• Ensure compliance with GCP and ICH guidelines and maintain inspection readiness
• Proactively manage operational risks and cross-functional dependencies
• Serve as a key operational partner to Clinical, Medical, and Regulatory teams
• Drive effective communication with internal stakeholders and external partners
• Operate successfully within a dynamic and collaborative biotech environment

Experience & Skills

• 10+ years of clinical operations experience, including late-stage development
• Demonstrated experience managing global Phase 3 clinical trials
• Strong background working with CROs, vendors, and international investigator sites
• Solid understanding of clinical trial operations, regulatory compliance, and inspection readiness
• Strong organizational, planning, and stakeholder management skills
• Ability to manage complexity and drive execution in fast-moving environments
• Comfortable working hands-on while maintaining program-level oversight
• Fluency in English (additional languages are a plus)